Nuclear hormone receptors

Nuclear hormone receptors - Nuclear hormone receptors...

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Nuclear hormone receptors Checkout principle singaling notes on nuclear receptors. Notes from handout: Nuclear receptors are of course located in the nucleus usually tightly bound to chromatin. Hormone traveling form the bloodstream dissociates with protein binding carrier and travels intracellularly (if lipid-soluble). It is brought into the nucleus by an intracellular recptor. Inside the nucleus the ligand-recptor complex dissociates and the hormone dimerizes onto the DNA where it reacts with the HRE. This activates transcription and so on. Specificity of heterodimeric nuclear recptor is achieved through spacing of nucleotides on the HRE (Hormone Response element). The arrangement is of 15 base pairs and is read by a DNA binding Domain (DBD). It usually is two hexad segments and 1-5 nucleotides separating them (1-2-3-4-5 rule). Mechanism nuclear receptor action. This figure depicts the mechanism of a class I nuclear receptor (NR) which, in the absence of ligand, is located in the cytosol. Hormone
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Nuclear hormone receptors - Nuclear hormone receptors...

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