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Immuno_I_S08 - Host Defenses Old Stuff Exam 3 Two parts...

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    Host Defenses Old Stuff: Exam 3 Exam 4 Two parts New stuff = 15% Comprehensive = 10% This Week: Host Defenses Next Week: Host-Microbe Interactions and  Epidemiology Last Week: Pathogens
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    Host Defenses Innate vs Acquired Innate: no memory Acquired: memory Line of division is artificial Innate and acquired strongly interact
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    Innate Immunity First – line defense Cells of the immune system Cell communication Sensor systems Phagocytosis Inflammation  Interferons Fever
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    First – line defense Physical barriers Antimicrobial substances Normal flora
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    Table 15.01a
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    Table 15.01b
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    Anatomical barriers Figure 15.1
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    Figure 15.3
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    Cells of the immune system Granulocytes Mononuclear phagocytes Lymphocytes
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    Granulocytes Table 15.2
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    Lymphocytes Figure 15.4
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    Cell communication Surface receptors Cytokines Adhesion molecules
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    Surface receptors Ligand Signal response - chemotaxis Specific
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    Cytokines Table 15.3
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    Adhesion molecules Allow cells to adhere to other cells Ex. Endothelial cells bind to phagocytic cells Slow down phagocytic cell movement
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    Sensor systems Toll – like receptors Complement system Classical pathway Alternate pathway
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    Toll – like receptors (TLRs) Figure 15.6
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    Complement system Figure 15.7
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    Phagocytosis Process of phagocytosis Macrophages Neutrophils
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    Process of phagocytosis Figure 15.9
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