Pharmacology_Test_3[1] - Pharmacology Test 3 Chapter 17 Adrenergic Agents(sympathetic fight or flight Stimulates A&B receptors Also known as Adrenergic

Pharmacology_Test_3[1] - Pharmacology Test 3 Chapter 17...

This preview shows page 1 - 3 out of 11 pages.

Pharmacology Test 3 Chapter 17 Adrenergic Agents (sympathetic/ fight or flight) Stimulates A&B receptors Also known as: Adrenergic agonists Adrenergic means describing nerve fibers that release “Norepinephrine” as a neurotransmitter” An agonist is a prime mover that causes an action. Sympathomimetics means a drug that has the effect of stimulating the sympathetic nervous system. Ex. Alpha and Beta Adrenergics are sympathomimetic drugs. Mimic the effects of sympathetic nervous system neurotransmitters: Norepinephrine (NE) is a hormone o causes constriction of small blood vessels which increases blood pressure; o increases blood flow to coronary arteries; slows down the heart rate; o increases the rate and depth of breathing; o relaxes the smooth muscle in the intestinal walls. Epinephrine (EPI) is a hormone o Increases the action of the heart o Increases the rate and depth of breathing o Raises the metabolic rate Adrenergic Receptors Alpha-adrenergic receptors: respond to NE Alpha adrenergic drugs constrict blood vessels (ex. Phenylephrine which constricts blood vessels in the skin and intestines, it is used as a nasal decongestant) Beta-adrenergic receptors: Respond to EPI Beta adrenergic drugs relax bronchial smooth muscle and are used as bronchodilators. (ex. Albuterol) Dompaminergic receptors: respond to Dopamine Vocabulary Beta-adrenergic receptors : receptors located on postsynaptic cells that are stimulated by specific autonomic nerve fibers. Beta1-adrenergic receptors are located primarily in the heart. Beta2-adrenergic receptors are located in the smooth muscle fibers of the bronchioles, arterioles and visceral organs. Mydriasis: pupillary dilation, whether natural (physiologic) or drug induced. Positive Chronotropic effect : an increase in heart rate ( speeds it up) Positive dromotropic effect : an increase in the conduction of cardiac electrical impulses through the AV node, which results in the transfer of nerve action potentials from the atria to the ventricles. This ultimately leads to a systolic heartbeat. Positive inotropic effect : an increase in the force of contraction of the heart muscle (myocardium) Blood vessels A1- constricts B2 dilates Cardiac muscle B1- increased contractility AV node B1- increased heart rate SA node B1- increased heart rate Liver A1 & B2- Glycogenolysis Kidney B1- increased renin secretion GI muscle A1 & B2- decreased motility Bronchial muscles B2- -Dilation Bladder sphincter A1- constrict Penis A1-Ejaculation Uterus A1- contraction B2-Relaxation Pupillary A1- Mydriasis (Dilates pupils)
Image of page 1
Alpha 2 Adrenergic Receptors: Located on presynatptic nerve terminals(the nerve that stimulates the effector cells) Control the release of neurotransmitters Vasoconstriction CNS stimulation Cause: Vasoconstriction of blood vessels Relaxation of gi smooth mscles Contratction of the uterus and bladder Male ejaculation Decreased insulin release Contraction of the pupils (dilated) mydryasis Beta-Adrenergic Receptors:
Image of page 2
Image of page 3

You've reached the end of your free preview.

Want to read all 11 pages?

  • Winter '16
  • heart rate, Adrenergic receptor

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

  • Left Quote Icon

    Student Picture

Stuck? We have tutors online 24/7 who can help you get unstuck.
A+ icon
Ask Expert Tutors You can ask You can ask You can ask (will expire )
Answers in as fast as 15 minutes