Lecture 9 Immune System-2007

Lecture 9 Immune System-2007 - Inflammatory and Immune...

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Inflammatory and Immune  Disorders:  Part I Lecture 9 Drugs for Inflammation, Allergies, and Immune  Disorders Drugs for Bacterial Infections
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Inflammation Inflammation A natural response that limits the spread of  invading microorganisms A complex process Occurs in response to many stimuli Central purpose of inflammation Contain the injury Destroy the foreign agent
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                 Inflammation Signs of inflammation Swelling  Pain  Warmth Redness
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Inflammation Acute vs. Chronic Acute  Injury or damaging agent is contained and  symptoms begin to resolve in 8 - 10 days Chronic Inflammation may persist for years Symptoms become progressively worse over  time Examples may include arthritis or lupus
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Inflammation Chemical Mediators Chemicals released by damaged tissue, a  response that alarms surrounding tissue Bradykinin – initiates pain response Complement – proteins, neutralize/destroy  antigen Prostaglandins – attract WBCs, cause pain
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Inflammation Histamine  Produces its effect by interacting with 2  different receptors H-1 Receptors Present in vascular smooth muscle, GI, bronchi Stimulation   itching, pain, edema,  vasodilation and bronchoconstriction H-2 Receptors Present in the stomach  Stimulation   secretion of large amounts of  HCl acid
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Inflammation Humoral Immunity Involves production of antibodies Antigen – foreign substance, elicits immune  response Lymphocyte (B-cells) – primary cells of immune  system that interact with antigens Activated B-cell clones itself (plasma cells) and produce  antibodies (immunoglobulins) specific to that antigen  (takes at least 10 days) Memory B-cells remember the antigen. If exposed again,  body produces more antibodies, faster~2 days
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                      Allergy  What is an allergy?  A hyper-response of body defenses Signs and symptoms are similar to those  of inflammation – due to histamine release Also involves mediators of the immune  system 
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Allergy                            Allergic Rhinitis Most common allergic disorder  Affects 15-20% of US population Inflammatory disorder of the nasal mucosa Symptoms  Sneezing, rhinorrhea (runny nose), watery eyes and nasal  congestion Occurs due to release of histamine and inflammatory  mediators in response to specific allergens Two forms Seasonal   outdoor allergens--hay fever (spring and fall) Perennial   indoor allergens, dust mites and pet dander  (not seasonal)
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This note was uploaded on 05/20/2008 for the course HSC 201 taught by Professor Jordan during the Spring '08 term at Ill. Chicago.

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Lecture 9 Immune System-2007 - Inflammatory and Immune...

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