salicylates2 - Salicylates Weak organic acid Drug MOA...

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Salicylates Weak organic acid Drug MOA Clinical uses Metabolism Effects Adverse reactions Miscellaneous Salicyclates Weak organic acid Aspirin (acetylsalicylic acid) Overall 1. Peripherally AND centrally acting 2. Inhibits PGs and TXAs Antipyretic ↓ pyrogen induced PGs and CNS response to IL1 Anti- inflam mator y 1. Reduce chemotaxic factors from macrophage s 2. stabilize lysosomes 3. inhibits migration of pain leukocytes and macrophage s Pain: 325mg every 4hrs : headache, myalgia, arthralgia, inflammation Fever: caution in children Acute rheumatic fever, rheumatoid arthritis: 4-6g/day Reduce risk of recurrent TIA and stroke, MI, unstable angina pectoris, colon cancer: 80- 160mg/day for chronic use Absorption from stomach and upper small intestine Distribution widely distributed Biotransformation rapidly hydrolyzed to free salicylic acid → biotransformed in liver to salicyluric acid and ester or ether glucuronides Saturation @ high doses and t 1/2 can increase from 3-12 hrs Excretion
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salicylates2 - Salicylates Weak organic acid Drug MOA...

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