chap.23-metabolism_Blei

chap.23-metabolism_Blei - IMPORTANT POINTS OF KREBS CYCLE...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
IMPORTANT POINTS OF KREBS CYCLE Two C’s enter the cycle and two C’s leave it (as two CO 2 ). The two lost C’s are not the ones that enter the cycle. In step 1, the citrate synthase is inhibited by ATP and NADH. In step 4, the dehydrogenase is inhibited by NADH and succinyl CoA. Step 4 is the only non-reversible step. One CO 2 is lost in step 3. One CO 2 is lost in step 4. Energy of the oxidation reactions is trapped as NADH in steps: 3, 4, and 8, and as FADH 2 in step 6. There is a substrate level phosphorylation in step 5 (GTP is formed from direct transfer of phosphate group) The whole process occurs in the mitochondria. It is the final common pathway for oxidation of carbohydrates, lipids, and proteins. MITOCHONDRIA It is an organelle made out of an outer membrane and an inner compartment (matrix) separated by an inner membrane. The matrix contains all Krebs cycle enzymes except the dehydrogenase of step 6. Step 6 dehydrogenase, the electrons transport chain enzymes, and the oxidative phosphorylation enzymes
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

chap.23-metabolism_Blei - IMPORTANT POINTS OF KREBS CYCLE...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online