Pysch 359- Learning

Pysch 359- Learning - Animal Behavior Testing Every mental...

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Animal Behavior Testing Every mental illness is a multigenetic disorder- Huntington’s, Cholera Isomorphic- combination of symptoms and treatment Homologous- cause, symptoms and treatments Predicted- treated Knock in Models-put in genes -AKA Transgenic Examples -S100B(chromosome 21(down syndrome)) - Double cortin overexpressing- make a transgenic model of making a mouse express a cortex twice -Human growth hormone expressing **Most people with down syndrome end up having Alzheimer’s. Knock out Models- take out genes Gene suppressed during childhood, expressed in adulthood Selective Breeding Breed animals that display certain phenotype - Generations later the trait is exaggerated
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Neurochemical Models Antagonistic or agonist drugs -Ex. Glutamate antagonist(animals can’t learn) -5-7DT kills serotonin neurons - 6-HDA- kills dopamine - PCPA- blocks tryptophan hydroxylase- to serotonin can be made Selective lesions -selectively remove neurotransmitter Deplete brain of neurotransmitter Environmental Models Stress model - Pup separated from mom - Restraint stress- tanning - Noise stress – white noise, predator noises - Environmental stress-rats don’t like living on an incline - Social Stress Other manipulations Hg Virus Insecticides / other fertilizers Animal Behavior Testing: Learning Learning areas:
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-Hippocampus - Frontal cortex - Amygdala - Cingulate Rodent behavioral testing mainly utilize - mazes Spatial Learning: Eight Arm Radial Maze: bait four arms for 7 days. Usually the same arm. Short Term errors: searched an arm already searched during the current trail
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Pysch 359- Learning - Animal Behavior Testing Every mental...

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