Problem Set 4 - Problem Set 4 1. Review the organization of...

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1. Review the organization of the endomembrane system. What are the basic patterns of trafficking within and beyond the endomembrane system? Why does the eukaryotic need so many membrane-bound compartments? Intracellular membrane organization: cytoplasmic (nucleoplasm and nuclear matrix; mitochondiral and chloroplast matrix) and exo-endoplasmic (nuclear envelope rough and smooth endoplasmic reticulum, golgi, lysosomes and various vesicle compartments. Endomembrane system: illustrated by biosynthetic/secretory pathways (constitutive, regulated exocytosis; endocytosis; anterograde, retrograde patterns of vesicle movement); cells have complicated pathways by which material (soluble protens, membrane proteins, lysosomal enzymes) are moved to and from the cell surface and other organelles. Endomembrane system: 1 Dynamic, integrated, ordered membrane bound 2 Nucleus, ER, Golgi, lysosomes, endosomes, vesicles 3 Best illustrated by biosynthetic and secretorypathways of the cell 4 Functions: protein (and lipid) synthesis, processing, sorting and packaging for specific target sites. 1 •Cells have complicated pathways ( TRAFFIC PATTERNS) by which materials are transported to and removed from membrane compartments 2 •Proteins –(soluble, secretory, membrane) are targeted to specific sites within or outside of the cell. 3 •SORTING/TARGETING: proteins have a specific address or signal encoded in the amino acid sequence or attached oligosaccharide that tell them where to go 2. What functions are associated with the endoplasmic reticulum? Why is one part of it called the rough endoplasmic reticulum? The smooth endoplasmic reticulum?? How might this part of the endomembrane system have given rise to the Golgi compartment? Rough (RER): system of interconnected flattened sacs with attached ribosomes. What Does the RER Do? 1 •A major site of the synthesis of proteins, lipids and carbohydrates; assembly and folding of proteins 2 •Proteins produced are several types: membrane, secretory, lysosomal. 3 •Best studied in cells that secrete large quantities of proteins (pancreatic enzymes; mucus-secreting cells lining the digestive tract) Smooth (SER): system of interconnected tubes without attached ribosomes What Does the SER Do? 1
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Problem Set 4 - Problem Set 4 1. Review the organization of...

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