Grignard Reagent

Grignard Reagent - Expoxidation of Cholesterol Experiment#1...

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Unformatted text preview: Expoxidation of Cholesterol Experiment #1 Purpose The experiment will focus on the creation of Grignard reagent phenyl magnesium bromide and its usage towards the synthesis of tertiary alcohol triphenylmethanol. Reaction efficiency will be measured by melting point, IR spectroscopy, and percent yield. Step 1: Creation of Grignard reagent Step 2: Creation of triphenylmethanol Results and Discussion Initial addition of the Grignard reagent to the ketone led to a milky solution indication of a precipitate. Addition of 5% HCL solution removed the precipitate. Isolation of the product led to only 0.385 grams of the compound, indicating a poor 38.92% yield. The poor yield was most likely due to the un-reacted magnesium during the creation of the Grignard reagent. Much of the Mg remained un-reacted despite rubbing with the glass rod. The obtained melting point of the product was 154 – 157 ºC. The value reported by literature was 163 ºC. The product had a melting point range of three degrees and melted prematurely by nearly 163 ºC....
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This note was uploaded on 05/25/2008 for the course CHE 326 taught by Professor Chisholm during the Spring '08 term at Syracuse.

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Grignard Reagent - Expoxidation of Cholesterol Experiment#1...

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