Lecture 18 - Lectur e 18 - Kar yotypes, Cytogenetics &...

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Unformatted text preview: Lectur e 18 - Kar yotypes, Cytogenetics & Genomic Sequences Keywor ds : Key Figur es : Kar yotype 8.1, 18.6 H ybr idization 20.2, 20.3, 20.18 Oligonucleotide Polymer ase Chain Reaction (PCR, pg. 503-504) FI SH ( Fluorescent I n Situ Hybridization) H ybr idization (Souther n Analysis) Pr obe Physical Map Suggest Pr oblems: None A high density map (Meaning lots of mar ker s for linkage analysis) But, how to get to genes? Differ ent types of maps: H ow to tie together , or navigate fr om one map to another ? N ow r eplaced by genome sequence data Cytological Mapping & Genome Sequences use the r eal chr omosomes (not abstr act gene idea and mutant phenotypes) - Essential for gene discover y: • Looking at the chromosomes – Karyotypes – Cytogenetics & FISH - Can tie the karyotype to the DNA • Looking at the DNA – Build a physical map - don’t have to worry about this too much, because…....
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This note was uploaded on 05/25/2008 for the course MCDB 2150 taught by Professor Winey,mark during the Winter '06 term at Colorado.

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Lecture 18 - Lectur e 18 - Kar yotypes, Cytogenetics &...

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