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Lecture 18 - Lecture 18 Karyotypes Cytogenetics Genomic...

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Lecture 18 - Karyotypes, Cytogenetics & Genomic Sequences Keywords : Key Figures : Karyotype 8.1, 18.6 Hybridization 20.2, 20.3, 20.18 Oligonucleotide Polymerase Chain Reaction (PCR, pg. 503-504) FI SH ( Fluorescent In Situ Hybridization) Hybridization (Southern Analysis) Probe Physical Map Suggest Problems: None
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A high density map (Meaning lots of markers for linkage analysis) But, how to get to genes?
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Different types of maps: How to tie together, or navigate from one map to another? Now replaced by genome sequence data
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Cytological Mapping & Genome Sequences use the real chromosomes (not abstract gene idea and mutant phenotypes) - Essential for gene discovery: Looking at the chromosomes Karyotypes Cytogenetics & FISH - Can tie the karyotype to the DNA Looking at the DNA Build a physical map - don’t have to worry about this too much, because…. The Genome Sequence - the ultimate map
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To understand hybridization & molecular markers, we need to remember a few things about DNA.
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