07Bionotes

07Bionotes - 11:32:00 AM Core concepts looking at idea of how do things get started in development Central Concepts in development o genes control

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02/11/2007 10:32:00 Core concepts: looking at idea of how do things get started in development. Central Concepts in development o genes control development most important concept in series of lectures o Cellular changes during development and cell differentianton result  form differential gene expression o Nuclear equivilance- all tpes of somatic cells retain all genes that were  presnt in the fetilzied eg. o Mechanisms of development are conserved. o Cytoplasmic inequivilence one side of the cell looks different from other side of the vell o Development results from a cascade of changes with each change  triggering the next o cells interact with one another in influence fate-induction (Monday) Production of differential gene expression o RNA and proteins are localized to one side of the cell o important in embryo.  Central Concept #5: Cell polarity and cytoplasmic inequivilance o Mother plays important role in polarity of the embryo o mother needs to set up axes very early on in order to male “front’  different from back in progeny. Model Organisms have helped solve the mysteries of development o it is very hard to study humans’ development o most of the developmental stuff happen in the dark womb o Time consuming to study o Model ogaisms have advantages Genetic Organisms Drosophila/ C. elegans Cheap and easy to grow
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Easy genetics Difficult surgical manipulations
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This note was uploaded on 05/26/2008 for the course MCDB 120 taught by Professor Johncarlsoncarolbascom-slackfrankslack during the Fall '07 term at Yale.

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07Bionotes - 11:32:00 AM Core concepts looking at idea of how do things get started in development Central Concepts in development o genes control

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