07 bionotes

07 bionotes - [email protected] IX The Eukaryotic...

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[email protected] 24/10/2007 10:29:00 IX The Eukaryotic Genome E. Gene Organization inYeast F. The Human Genome X. The control of Eukaryotic Gene Expression A. Differential Gene Expression B. RNA Polymerases C. Promoters and Enhancers D. Transcription Factors Gene organization genome project. One of the first eukaryotic genes to be sequences was yeast  genome o very dense with genes 72% of yeast’s genome sequence encodes protein There are about 6000 coding proteins in yeast o 40% of these genes encode membrane proteins o there are a few hundred base pairs in between genes o very few introns in yeast genes  One can put a DNA sequence into a database to see if it matches anthing  else that has beeen identified Ataxia Telangiectasia: people studying genome has new insight  into molecular and cellular basis based on the database A lot of human disease genes have homologues o In 2001, there were two reports published showing the sequnce of the  human genome. Science and nature magazines published articles  about human genome o www.ncbi.nlm.nih.gov   o various people’s sequences were analyzed. Different racial groups open reading frames were looked for: genes that encode  proteins humans have 25,000 genes. People expected far more
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only about 25% more than genes in tiny worm. Blamed  computer program. Controversy.  What do genes encode? o about 5% had sequences that looked like receptor proteins. 3% looked  that they encoded  kinases  o Human Genome: only 1% coding for protein 99% is noncoding 1.1% is exon 24% intron 75% intergenic (between genes) Yeast was very different from humans 
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07 bionotes - [email protected] IX The Eukaryotic...

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