Problem_set_04_key

Problem_set_04_key - Huxford—Spring 2008 J KW Chem 365 %...

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Unformatted text preview: Huxford—Spring 2008 J KW Chem 365 % Molecular & Cell Biology Practice problem set 4 I) From VV P, Chapter 4 Problems 3, 4, 6 and 9 2) Draw the amino acid L—Tyrosine in its fully protonated form. Show the proper stereochemistry. COG H B H CUOH _ Hr? \ 0H / ._ "' N' :3 3) Sketch a titration curvéJfF’or the amino acid tyrosine. (Hint: plot pH on the y—axis and equivalents of base on the x-axis) mug‘ ‘““ GS“ I .0 3.0 _ . . (3 r 4) a) What is the singjé e “‘e‘igcbfi’g‘fo‘flézrosme? b) What is the charge on the prevailing species of tyrosine at pH 12‘? c) Calculate the isoelectric point (pl) of tyrosine. CL) Y __'l a) 2,13 fig 2.: -;_,g F L (i-xpwfé‘ +( O -.‘ - 2. H t L r'c s‘ ) 5) Drai‘w the amino acid L—histidine in its fully protonatec? form. Show the proper stereochemistry. C be H cccH *1. + H ’36 “M H H . i, /’ f. + 6) Sketch a titration curve for the amino acid histidine. 6%? 7 t“ L 3.; u; as 25% m _ 7) a) What is the sifie‘l'étf' a fir liigrtidine? b) What is the charge on the prevailing species of histidine at pH 7 0) Calculate the isoelectric point (pl) of histidine. din bit” c) fish—Ti}; t Huxford—S prin g 2008 [Eu-{3“ O" NHB+ CH3 ngN H l 32 5 H *H N I 'O\ NH 7*" CH2 0 “‘5’” 3 c cu3 cf _ \ of \c”! \ Hallo/“XS”; a” CH: 0—0 G NH2 HE C _| H: o I" / “‘0 C 0 0 "O .0/ \\O / HN I II I" IV 8) The chemical structures of four amino acids are depicted above and they are labeled I, II, III, and IV. Use your knowledge of amino acid nomenclature, structure, and chemistry to answer the following questions. Answer with the Roman numeral unless otherwise instructed. A) What is the single letter code of amino acid I? B) Which of these does not carry a neutral charge at pH 7? “if C) Which amino acid is classified as aromatic? ( {A} I. F, II D) Which is shown above as a D—amino acid? I E) What is the three letter code of amino acid III? Ila F) What is the isoelectric point (pl) of I? I : u a _ r .3: ,g s; c G) Which has a chiral center within its side group? H) Which amino acid contains the indole side group? TI 1) Which cannot form hydrogen bonds through its side group? J) Which will elute last from (or bind most tightly to) an anion exchange column? I K) Which has a polar uncharged side group? I L) Between amino acid II and amino acid III, which would you most expect to see buried in the core of a globular protein? LIL ...
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This note was uploaded on 05/12/2008 for the course CHEM 365 taught by Professor Huxford during the Spring '08 term at San Diego State.

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Problem_set_04_key - Huxford—Spring 2008 J KW Chem 365 %...

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