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Unformatted text preview: 3/12/2008 1 Endocrinology II Endocrinology II • 3 main types of transduction • All involve specific protein receptor only found in correct target cell. • Receptor-hormone complex mediates the specific change in target cell – resulting in either enzyme or gene activation Signal transduction Signal transduction either enzyme or gene activation • Must have some way of turning the system off The multifunctional epinephrine! The multifunctional epinephrine! • 3 main types of transduction 1) Signal transduction of steriods- steriods are non-polar, lipid soluable- transported by carrier molecules in blood - can pass freely across cell membrane Signal transduction Signal transduction- bind with cytoplasmic or nuclear receptor proteins- allows for production of new protein and enzymes • 3 main types of transduction 2) Signal transduction of thyroid hormones- transported by carrier molecules in blood - also non-polar, so can pass freely across cell membrane Signal transduction Signal transduction- its receptor is on the nucleus of the target cell- allows for production of new protein and enzymes 3/12/2008 2 • 3 main types of transduction 3) Signal transduction of polar hormones- includes catecholamines and peptides - since it can’t get into the cell it needs a 2 nd messenger inside the cell Signal transduction Signal transduction- 2 nd messengers include cAMP or Inositol triphosphate (IP 3 ), 3 rd messenger is calcium • Several major players: 1) Brain – hypothalamus, pituitary- both closely tied and connected by blood supply thru a portal system- hypothalamus receives sensory input from brain System control – the cascade! System control – the cascade!- sends chemical signal to the pituitary- pituitary then sends another chem. signal to target organ(s) 2) Target organs (other endocrine organs) – pancreas, gonads.. • 9 formal endocrine organs (several are 2 in 1) • 10 other organs with 2 ° endocrine-like functions • Targets may be specialized, narrow group of tissue Endocrine organs Endocrine organs tissues • Others have broader range of tissues/organs • Some targets other endocrine organs Hypothalamus – makes releasing hormones to stimulate pituitary Pituitary – makes tropic hormones that act on still other endocrine glands Hypothalamus – in the brain, is master control center- integrates nervous and endocrine systems- sensory info goes to hypothalamus for integration- contains specialize neuron called Endocrine organs Endocrine organs contains specialize neuron called neurosecretory cells that receive input from sensory neurons and interneurons- respond by synthesizing and releasing peptide hormones into blood- two populations of neurosecretory cells Hypothalamus – in the brain, is master control center- one set produces hormones that are carried in the neurosecretory cell axon to the posterior pituitary (PP) for release into the blood at the gland Endocrine organs Endocrine organs- Exp/ ADH and oxytocin – both small peptides...
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This note was uploaded on 05/18/2008 for the course BIOL 211B taught by Professor Lowe/zahn during the Spring '08 term at CSU Long Beach.
- Spring '08