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12_ImmunEndocrin_45_S08 - Immune function and Endocrinology...

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3/10/2008 1 Immune function and Endocrinology Quiz questions: 1. Which is not a lymphoid organ? A) lymph node, B) thyroid gland, or C) spleen. 2. The typical fraction of cells to plasma in blood: A) 45%, B) 55%, or C) 70%. 3. Which vessels lack muscles or check valves to augment flow: A) veins B) arteries or C) A) veins, B) arteries, or C) lymphatic vessels. 4. Blood platelets are formed from… A) RBCs, B) megakaryocytes, C) plasma, or D) WBCs 5. The most abundant type of WBC in a health human are A) eosinophils, B) monocytes, C) lymphocytes, or D) neutrophils. Immune responses: Neutrophils and macrophages eat cells Complement tags cells to be eaten ( but they are not specific to any one antigen ) Two other specific responses: 1) Humoral/antibody response - lymphocytes produce specific antibodies - lymphocytes produce specific antibodies, which can act as tags or agglutinate - some cells are set aside as memory cells 2) Cell mediated response - lymphocytes directly attack infected cells Immune responses: • Macrophages: - Chompers! Phagocytize cells and particles - alert helper T-cells • Lymphocytes: Key players: - B-cells (mature in bone marrow) and T-cells (mature in Thymus) - hangouts: lymph nodes, spleen, appendix, other lymphoid tissue - favorite things: like to fight! Immune responses: • B-cells: - make IgD antibodies - when activited (with help from helper T-cells) can do a variety of things: 1) produce plasma cells – antibody factories! Key players: 2) produce memory cells – can retain antibodies over time, ready for reinfection (2 nd immune response) faster than the 1 st ! Immune responses: • T-cells: - Thymus secretes thymosin to activate T-cells - when activited, T-cells become: 1) Helper T-cells (T h cells) – activate by binding w/ macrophages, secrete t ki Key players: cytokines 2) Killer T-cells – directly destroy tumor cells of body or those already infected 3) Suppressor T-cells – control rate of immune response by binding to T-cells 4) Memory T-cells – persist in body for months ready to fight reinfection
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3/10/2008 2 Figure 43.10 An overview of the immune responses (Layer 4) Types of immune responses and immunity 1º immune response – after 1 st exposure to antigen. 2º immune response – after 2 nd exposure to antigen Much faster because of clones antigen. Much faster because of clones and memory cells Active immunity – body responds by producing antibodies to combat antigens Passive immunity – introducing antibody for particular antigen into the body. How would passive immunity occur? Injected to prevent disease Treatment of diseases From mother’s blood (placental crossing) and mother’s first milk Allows for the individuals immune system to build up their own antibodies.
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12_ImmunEndocrin_45_S08 - Immune function and Endocrinology...

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