Exam3-03_key - BMB 401 Exam 3 Kaguni Section: 15 questions,...

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BMB 401 Exam 3 Kaguni Section : 15 questions, 4 points each, 60 points subtotal. 1. Select the correct statement. In eukaryotic DNA replication,: a. DNA polymerase III holoenzyme is the replicative helicase. b. a helicase acts at the replication fork to unwind the parental duplex DNA. The single stranded DNA produced by this unwinding is then bound by RPA. c. Initiation Factor 2 (eIF2) binds to the replication origin to initiate DNA replication. d. telomerase, as a complex of protein and DNA, utilizes the DNA component as a template to synthesize telomere repeat sequences. 2. Select the correct statement. a. The repair of thymine dimers by photolyase is an example of direct reversal of the DNA damage. b. Thymine dimers are formed by oxidative damage of DNA. c. A thymine dimer is formed between a thymine residue in one DNA strand and a thymine residue in the complementary DNA strand of a duplex DNA molecule. d. Thymine dimers are produced by photolyase. 3. Select the correct statement. a. Reverse transcriptase is an enzyme that repairs damage in DNA. b. Mispairing of A in one DNA strand (let’s call this the Watson strand) with C in the other DNA strand (the Crick strand) of duplex DNA results in the replacement of an AT base pair with a CG base pair. c. Excision repair coupled to transcription by RNA polymerase involves the replacement of damaged DNA with RNA. d. Fen1 endonuclease excises the DNA damage produced during DNA replication. 4. Select the correct statement on eukaryotic DNA replication. a. Replication Protein A (RPA, also known as Replication Factor A (RFA)) is equivalent in function to DNA ligase of E. coli . b. DNA polymerase delta is a trimer of identical subunits that has a ring-shaped structure. c. DNA synthesis occurs during the G1 phase of the cell cycle. d. The interaction of DNA polymerase delta with RFC (Replication Factor C, also known as Replication Protein C (RPC)) makes this DNA polymerase highly processive. 5. Select the correct statement. a. A messenger RNA is composed of codons in which the first incorporated nucleotide of the RNA polymer corresponds to the first nucleotide of the first codon. b. Transcription forms an RNA polymer that is complementary in sequence to the nontemplate strand of the DNA transcribed. c. Transcription occurs in the 5’-to-3’ direction relative to the RNA polymer being synthesized. d. A messenger RNA is composed of codons in which the first incorporated nucleotide of the RNA polymer corresponds the third nucleotide of the codon. 6. Select the correct statement. a. Transcriptional initiation involves the sequential steps of formation of the Open Complex followed by formation of the Closed Complex, then the incorporation of6-10 ribonucleotides before the Sigma Factor is released from RNA polymerase. b.
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This note was uploaded on 05/21/2008 for the course BMB 401 taught by Professor Kaguni during the Spring '08 term at Michigan State University.

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Exam3-03_key - BMB 401 Exam 3 Kaguni Section: 15 questions,...

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