Lect5folding

Lect5folding - But, cellular concentration of proteins ~300...

Info iconThis preview shows pages 1–24. Sign up to view the full content.

View Full Document Right Arrow Icon
The sequence that you used the BLAST algorithm to identify is a: A.Rodent preproinsulin B.Human insulin C.Chimp insulin D.Human preproinsulin E.I didn’t do the exercise yet.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 4
Fig. 4-27 Lehn
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig. 4-27 Lehn
Background image of page 6
Fig. 4-28 Lehn
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig. 6-2 B and T
Background image of page 8
Molten Globule Final folded form
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig. 6-5 B and T
Background image of page 10
Fig. 4-29 Lehn
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Crowded cytoplasm (tRNA in blue, ribosomes in green, proteins in red)
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Molecular Chaperones function analogously to human counterparts: “They inhibit inappropriate interactions between potentially complementary surfaces and disrupt unsuitable liasons so as to facilitate more favorable associations” John Ellis
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
General Features of Chaperones • Proteins that catalyze the folding of other proteins – Folding information in primary sequence of proteins
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 20
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 22
Background image of page 23

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 24
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: But, cellular concentration of proteins ~300 mg/ml Aggregation Rate of chain elongation is ~ 4 amino acids/second, so about ~ 4 minutes for a 1000 residue protein Exposed hydrophobics Initially identified as proteins induced by heat shock heat shock proteins (Hsp) Peptide prolyl cis-trans isomerase (PPI) catalyzes this reaction Protein disulde isomerase (PDI) can greatly speed up this reaction Given the enzymatic activity of a PDI (protein disulfide isomerase, where do you expect most of this enzyme to be found in a eukaryotic cell? A.Nucleus B.Cytosol C.Endoplasmic reticulum D.Cell surface E.On or near Ribosomes...
View Full Document

Page1 / 24

Lect5folding - But, cellular concentration of proteins ~300...

This preview shows document pages 1 - 24. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online