Lecture_19_04_22_neuro_1660

Lecture_19_04_22_neuro_1660 - 1 Mayank Mehta NEURO 1660 1...

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Unformatted text preview: 1 Mayank Mehta NEURO 1660 1 Lecture Lecture 19 19 Oscillations, synchrony, learning Oscillations, synchrony, learning and anticipation and anticipation 1. Mehta, Neuroscientist , 2001 2. Winson 1979 3. O’Keefe & Recce, 1993 4. Mehta et al. 2002 5. Zugaro et al. 2005 6. Engert et al. 2002 7. Schwartz, Berry et al. 2007 Mayank Mehta NEURO 1660 2 How can sequence learning in one-dimension help learning in more complex conditions? • In a computational model of learning Morris water maze, population of place cells begin to point towards the hidden platform with experience. Gerstner & Abbott 1998 Mayank Mehta NEURO 1660 3 Spike timing dependent Spike timing dependent plasticity (STDP) plasticity (STDP) Spatio Spatio-temporal temporal receptive fields receptive fields Sequence learning, Sequence learning, navigation navigation ? ? ? ? 10-4 s 10 s 10 3 s Now we will discuss the role of behavior and ‘brain’ in generating spike timing related to STDP Mayank Mehta NEURO 1660 4 Velocity LFP __________________ 1000 ms Hippocampus shows 8 Hz theta rhythm Hippocampus shows 8 Hz theta rhythm when the rat runs when the rat runs 2 Mayank Mehta NEURO 1660 5 Removal of the medial septum impairs Removal of the medial septum impairs navigation ( navigation ( Winson Winson 1978) 1978) Mayank Mehta NEURO 1660 6 Problem: NMDA dependent plasticity (STDP) depends critically on spike timing Markram Markram & Sakmann, & Sakmann, 1996, 1996, Bi & Bi & Poo Poo , 1998 , 1998 Mayank Mehta NEURO 1660 7 Can we generate precise spike timing, appropriate for STDP, in Vivo? •Learning by STDP requires precise spike timing: Pre- & post-synaptic neurons should fire in a precise temporal order. Mayank Mehta NEURO 1660 8 To learn temporal sequences, behavioral order of events should be preserved on short time scales 100 ms Time Probability of Spiking 3 Mayank Mehta NEURO 1660 9 100 ms Time Probability of Spiking If information is encoded purely by a rate code, behavioral order of events is poorly represented on short time-Scales Mehta et al. Nature 2002 Mayank Mehta NEURO 1660 10 Can one generate precise spike timing, appropriate for STDP, in Vivo?...
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Lecture_19_04_22_neuro_1660 - 1 Mayank Mehta NEURO 1660 1...

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