Lecture_20_04_24_neuro_1660

Lecture_20_04_24_neuro_1660 - Lecture 20 Sleep and Memory...

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1 Mayank Mehta NEURO 1660 1 Lecture 20 Lecture 20 Sleep and Memory Sleep and Memory 1. Rausch, Born et al. Science 2007 3. Hahn et al. Nature Neuroscience 2006 4. Hahn et al. PNAS 2007 5. Mehta, Nature Neuroscience 2007 Mayank Mehta NEURO 1660 2 Why do we sleep? • Evolutionary mechanism to keep is immobilized and out of harm’s way when it is dark? • To save energy by reducing metabolism? • If so, why is the brain active during sleep? • Consolidation: Do short-term memories turn into long- term memories during sleep? • Rapid eye movement sleep (REM). – Theta rhythm in the hippocampus! • Slow wave sleep (SWS). – Slow oscillations in the neocortex, no oscillation in the hippocampus (Large irregular activity (LIA)). • What is the evidence that hippocampus dictates to neocortex during sleep? Mayank Mehta NEURO 1660 3 Synchronized slow oscillations during SWS and anesthesia: Up-Down states (UDS) Local field potential (LFP) from multiple brain neocortical brain regions shows synchronized slow oscillations during SWS and under anesthesia. Neurons are spontaneously active during the ‘UP’ state. Neurons are mostly quiet during the ‘DOWN’ state. Hahn, Sakmann, Mehta, Nature Neuro 2006 Mayank Mehta NEURO 1660 4 Sleep smell and memory: Task • Task: Take medical students! • Ask them to memorize where some object belong on a 2D grid. • Let them go to sleep. • Vary the odors during behavior and during sleep. • Measure the subsequent recall of objects the next day. Rasch, Born, Science 2006
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2 Mayank Mehta NEURO 1660 5 Sleep smell and memory: Task • Experiment 1: present odor (rose) during learning and during the first part of SWS.
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This note was uploaded on 05/17/2008 for the course NEUR 1660 taught by Professor Mehta during the Spring '08 term at Brown.

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Lecture_20_04_24_neuro_1660 - Lecture 20 Sleep and Memory...

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