Lecture_13_03_13_neuro_1660

Lecture_13_03_13_neuro_1660 - Lecture 13 Prefrontal cortex:...

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Mayank Mehta, NEURO 1060 Lecture 13 Prefrontal cortex: Working memory, executive function etc. P. G. Rakic, Circuitry of primate prefrontal cortex and regulation of behavior by working memory, Review article on Prefrontal cortex and working memory. Miller and Cohen, An integrative theory of prefrontal cortex Annual Rev. of Neurosci, 2001 Rainer, Assad, Miller, selective representation of relevant objects in the primate prefrontal cortex, Nature, 1998 Furster, Prefrontal cortex –An Update: Time is of Essence Mayank Mehta, NEURO 1060 Prefrontal cortex Dorsal stream, parietal cortex ‘Where’ or object location Ventral stream, IT cortex ‘What’ or object identity Prefrontal cortex: Integration of What and Where, Working memory, Executive control Rakic, Review Mayank Mehta, NEURO 1060 Relative size of prefrontal cortex is large in humans: Occupies about 30% of the neocortex Rakic, Review Mayank Mehta, NEURO 1060 Prefrontal cortex damage and effect on behavior • Intact perception and motion! – Lobotomy and the Hungarian twist. • Altered personality. – Lobotomy • Lack of impulse control. – Lack of initiation of action, and cessation of action. • Loss of interest in events. • Aggression. • Lack of attention? • Lack of working memory.
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Lecture_13_03_13_neuro_1660 - Lecture 13 Prefrontal cortex:...

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