Lecture_14_03_18_neuro_16601

Lecture_14_03_18_neuro_16601 - Lecture 14 Neural Plasticity...

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1 Mayank Mehta NEURO 1660 Lecture 14 Lecture 14 Neural Plasticity Neural Plasticity 1. Mehta, Neuroscientist , 2001 2. Markram & Sakmann, Science , 1997 3. Dudek & Bear, PNAS 1992 PNAS 1997 5. Buonomano & Merzenich, Annual Rev. Neurosci , 1998 6. Harvey, Svoboda, Nature 2007 7. Mehta, TINS 2004. Mayank Mehta NEURO 1660 Outline Outline • Plasticity of synapses Plasticity of synapses – Rate based protocol Rate based protocol – Timing based protocol Timing based protocol • Plasticity of cortical maps Plasticity of cortical maps • Plasticity of receptive fields Plasticity of receptive fields Mayank Mehta NEURO 1660 Cellular and synaptic Cellular and synaptic properties properties Neuronal networks, Neuronal networks, Receptive Fields . .. Receptive Fields . Behavior, Behavior, Disease Disease •Can the conditions required for inducing synaptic plasticity occur during behavior? •What are the emergent properties of synaptic plasticity on the receptive fields? •How does the plasticity of receptive fields relate to behavioral learning? ? ? ? ? 1 10 4 10 14 10 -4 s 10 0 s 10 3 s Mehta, Neuroscientist 2001 Mayank Mehta NEURO 1660 Synaptic plasticity Groups of neurons which tend to fire together form a cell-assembly whose activity can persist after the triggering event and serves to represent it. Donald Hebb (1949, Organization of Behavior)
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2 Mayank Mehta NEURO 1660 Synaptic plasticity Thinking is the sequential activation of sets of cell- assemblies. Donald Hebb (1949, Organization of Behavior) Mayank Mehta NEURO 1660 Synaptic plasticity When an axon of cell A is near enough to excite B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes
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Lecture_14_03_18_neuro_16601 - Lecture 14 Neural Plasticity...

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