Lecture_17_04_10_neuro16600

Lecture_17_04_10_neu - Lecture 16 1 2 3 4 5 6 7 8 9 Mehta Neuroscientist 2001 Muller Kubie 1987 Quirk Muller Kubie 1990 Muller Taube 1996 Russel et

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1 Mayank Mehta NEURO 1660 Lecture Lecture 16 16 1. Mehta, Neuroscientist , 2001 2. 3. Quirk, Muller, Kubie, 1990 4. Muller, Taube, 1996 5. Russel et al. 2003 6. Save, Nerad, Poucet, 2000 7. 8. Hampson, Deadwyler, 1999 9. Redish, Barnes et al. 20001 10. Ekstrom, Fried et al. 2003 11. Hafting, Moser et al., 2005 13. Calton, Taube et al., 2003 Mayank Mehta NEURO 1660 Hippocampus is critical for learning Hippocampus is critical for learning •Anterograde Amnesia (Milner, Squire, Corkin). •Alzheimer’s disease, Schizophrenia, PTSD, Epilepsy •Patient HM •Short term memory deficits. Old memories are intact! •Consolidation of short term memories from the hippocampus to the cortex for long term storage during sleep (Marr, …). Mayank Mehta NEURO 1660 Morris water Maze: Role of hippocampus in learning Mayank Mehta NEURO 1660 Role of hippocampus in behavioral learning Role of hippocampus in behavioral learning •Anterograde Amnesia (Milner, Squire, Corkin). •Short term memory deficits. Old memories are intact! •Consolidation of short term memories from the hippocampus to the cortex for long term storage during sleep (Marr, …). •Hippocampal lesion produces navigational impairments in rodents (Morris, …). •NMDA antagonists result in navigational impairments (Morris, …). •Transgenic mice without NMDA receptors in hippocampus are impaired on navigational tasks (Tonegawa, …). •How?
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2 Mayank Mehta NEURO 1660 Behavioral correlates of Behavioral correlates of hippocampal hippocampal activity activity •Formation of new memories. Consolidation: Corkin, Dudai, Eichenbaum, Milner, Squire, Zola-Morgan •fMRI signal in hippocampus in memory related tasks:
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This note was uploaded on 05/17/2008 for the course NEUR 1660 taught by Professor Mehta during the Spring '08 term at Brown.

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Lecture_17_04_10_neu - Lecture 16 1 2 3 4 5 6 7 8 9 Mehta Neuroscientist 2001 Muller Kubie 1987 Quirk Muller Kubie 1990 Muller Taube 1996 Russel et

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