Lecture_5_02_12_08_NEURO_1660

Lecture_5_02_12_08_NEURO_1660 - Nose CH 3 O H 3C CH3 CH3 O...

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1 The molecular Logic of Smell Olfactory bulb Olfactory Epithelium
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2 Tit le Different Sensory Modalities Employ Receptor Repertoires of Vastly Different Size G-protein Coupled Receptors SYNAPTIC CLEFT ENDOPLASMIC RETICULUM 5HT IP3 DAG Ca 2+ Ca 2+ CaMKII PKC IP3R PLC β G α q (GTP) G α q G βγ βγ G βγ 2c PIP2 GTP GDP
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3 Crystal structure of bovine rhodopsin Science (2000) 289:739 Ligands for GPCRs - Photons - Peptides - Hormones - Amino Acids - Small molecules Topologies GPCR Dimers Javitch, Molecular Pharmacolory 66:1077, 2004 Filipek et al., Photochem. Photobiol. Sci 3:628, 2004 Signal Transduction through an Activated Dimeric GPCR to its Cognate G-protein
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4 Schematic of olfactory system Organization of the Olfactory System Point to point Random Convergent Models of Connectivity
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5 Neurons Expressing the Same Receptor Converge to the Same Glomerulus R1 R2 R3 R4 R5 R6 R1 R2 R3 R4 R5 R6 Deconstruction of Odor Identity in the
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Unformatted text preview: Nose CH 3 O H 3C CH3 CH3 O O H3C CH3 CH3 O O H3C HO HO CH3 CH3 The Pattern of Active Glomeruli Represents Odor Identity 6 Staining of Olfactory Neurons with anti MOR28 MOR28 Protein is Present in the Axon Terminal Cytoplasmic Extracellular Merged MOR28-ires-τ-LacZ -/+ β Gal MOR28 Merged Anti-MOR28 Antibodies Stain the MOR28 Glomerulus 7 Deterministic Choice of Receptor Alleles Stochastic Choice of Receptor Alleles Switching A Functional Receptor Stabilizes Receptor Choice 8 A Single Enhancer Selects 1 out of 1500 genes Damien Hirst, Argininosuccinic Acid 1995 Projections of the Main and Accessory Olfactory Systems The Pattern of Active Glomeruli Represents Odor Identity...
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This note was uploaded on 05/17/2008 for the course NEUR 1660 taught by Professor Mehta during the Spring '08 term at Brown.

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Lecture_5_02_12_08_NEURO_1660 - Nose CH 3 O H 3C CH3 CH3 O...

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