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Unformatted text preview: No signals apoptosis! Ligands =Stimili (molecules, viruses, light, gases, a.a., proteins, nucleotides, steroids) cannot penetrate selectively permeable plasma membrane Receptors almost always proteins, transduece signal to inner cell Types of Signals autocrinerelease of ligand that acts on the own cell paracrine(endocrine) ligand acts on adjacent cells (over larger distance) (Vit D) Nuclear/ (Steroid/Hormone) Cytosolic/Surface Receptors all have DNA, ligand binding domain and activation domain (to recruit RNAP) What happens when one of these domains is mutated? NLSmasked or exposed masked on Cytosoliccc by binding of ligand unmasked on Nuclear...
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- Winter '08
- cell biology