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Unformatted text preview: expression of monomeric ligand on the signaling cell. (lipid rafts) Specific Signaling Pathways Receptor Transducing signaling proteins Outcome/Details TGFb-family receptors Smads Stop cell proliferation Similar to nuclear hormone receptors (NLS exposed by HDAC-histone deacetylase shuts down transcription Cytokines Janus Kinases /STATs Receptor recruits a kinase (JAK) SH2 domain of STAT loves to bind to phosphorylated tyrosines Receptors are inactivated by dephosphorylation of enzyme Or marked for degradation Receptor Tyrosine Kinase Ras/MAP kinase Similar to Jak/STAT but have INTRINSIC KINASE activity LEC 19 details about Ras/MAP(KKK)...
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