W7OutlineLec19

W7OutlineLec19 - expression of monomeric ligand on the...

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 7 Lecture 19 Outline 2/22/08 Enzyme Linked Coupled Receptors Receptor Transduction signaling proteins TGFb-family receptors Smads Cytokine receptors JAK's / STAT's Receptor tyrosine kinases Ras / MAP kinase Receptors generally… have INTRINSIC enzyme activity OR another protein will bind to the receptor that will give kinase/phosphotase activity monomeric or dimerized forms Receptor Activation -ligand binds and subunits are activated Monomeric ligands can be concentrated locally by extracellular matrix proteins . Receptors are brought into close association by binding to ligand. Clustering of receptors can also be induced by localized
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Unformatted text preview: expression of monomeric ligand on the signaling cell. (lipid rafts) Specific Signaling Pathways Receptor Transducing signaling proteins Outcome/Details TGFb-family receptors Smads Stop cell proliferation Similar to nuclear hormone receptors (NLS exposed by HDAC-histone deacetylase shuts down transcription Cytokines Janus Kinases /STATs Receptor recruits a kinase (JAK) SH2 domain of STAT loves to bind to phosphorylated tyrosines Receptors are inactivated by dephosphorylation of enzyme Or marked for degradation Receptor Tyrosine Kinase Ras/MAP kinase Similar to Jak/STAT but have INTRINSIC KINASE activity LEC 19 details about Ras/MAP(KKK)...
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This note was uploaded on 05/28/2008 for the course BIOL D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.

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W7OutlineLec19 - expression of monomeric ligand on the...

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