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Unformatted text preview: cycle (Details in Lec 21)-work by regulating Cyclin/CDK Is a cell cannot stop from going from G0 to G1? It would • Get huge • Possible get cancer GENERAL OVERVIEW (BASIC Description) – Basic principle of control of cell cycle involves production of kinase activity at different stages during cell cycle – Cyclin+CDK complexes that vary throughout cell cycle – CDK does not work without proper cyclin – Cyclin concentration rises/falls throughout cell cycle – Degradation of cyclins Is very important (for progress through cell cycle) by ubiquitination – CDK are present ALL the time, Cyclin concentration reaches a threshold and CDK activity is TURNED ON – Cyclin must be broken down before going on to cell cycle Mitogens: cause cell division (mitosis) Growth Factors: increase cell mass (protein synthesis)...
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