W9OutlineLec24 - 6. Disassemble the scaffold, reform the...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Luis David Gomez Week 9 Lecture 24 Outline 59866865 Bio 192 D103 Cell Biology 3/5/08 Mitosis and Cytokinesis Things to do --Overview 1. No new protein synthesis after entry into mitosis better retain proteins required for life immediately after cytokinesis ! 2. Condense chromosomes before trying to separate them think you can quickly separate many balls of unwound string ? 3. Disassemble nuclear envelope can you connect chromosomes to the centrosomes while the nuclear envelope is in between them ? 4. Ensure that sister chromatids can be reliably and quickly sorted one per daughter cell how can we make a dynamic scaffold that allows us to assemble and move chromosomes ? 5. Ensure that a set of chromosomes and adequate organelles are partitioned to each daughter cell better make sure that you divide the cell in the right place !
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 6. Disassemble the scaffold, reform the nuclear envelope, allow chromatin to reorganize How to accomplish this without significant new protein synthesis ? Review Details S-Phase: Sister Chromatids=duplicated chromosome held together by centromere (where kinetechore is formed) Interphase: Centriole+ gamma tubulin + pericentriolar maxtrix (RNA, other proteins) = Cetrosome, which replicates during this phase Prophase: Half-Life of Microtubules: decreases from 10 min to .5 min High levels of Stabilizing map during interphase, LOW levels of stabilizing map during mitosis Dissassembly of Golgi: CDK-1 Phosphorylates GM-130 (t SNARE) so that p-1115 (v SNARE) cant recognize each other DNA Condensation Sister Chromosomes held together by COHESIN Once mitosis occurs, CONDENSINS package DNA closer...
View Full Document

This note was uploaded on 05/28/2008 for the course BIOL D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.

Ask a homework question - tutors are online