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W9OutlineLec25 - Frogs Urchins Biochemistry—look at...

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 9 Lecture 25 Outline 2/22/08 Cell Cycle I cont. Inhibitor of Cdk/Cylcin Cdk has two domains: an ACTIVATION DOMAIN and an INHIBITORY domain. CAK (cdk activating kinase)—add a phosphate to CDK to activate it BUT… Wee-1 –adds a phosphate to the CDK to inhibit it THEN Cdc-25 (after being phosphorylated/activated by cyclin) – removes the inhibitory phosphate added by Wee-1 How do we study mitosis
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Unformatted text preview: ? Frogs Urchins Biochemistry—look at fractions of cell extracts Each time you go through the cell cycle, proteins must be synthesized newly from RNA Lec 22 How is mitosis controlled? Synthesis of cyclin be causes Mitosis promoting force. Cyclins must be degraded in order to continue through cell cycle How are cyclins destroyed? Destruction box—a.a. sequence that causes degradation by binding of appropriate proteins...
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