W3OutlineLec8

W3OutlineLec8 - Luis David Gomez 59866865 Bio 192 D103 Cell...

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 3 Lecture 8 Outline 1/ 25/08 Microtubules alpha and beta tubulin both have GTP binding site, only hydrolyzed on Beta tubulin assamble into heterodimer Do MT treadmill? No because you only have one free end, the other is MTOC The correct conditions for treadmilling: high concentration than Cc, polar structures. Centrosomes y-tubilin cap—“nucleating” site for MT What leads to dynamic instability? Monomers form heterodimers—and with a slight delay the GTP will be hydrolyzed This delay lead to the formation of a GTP cap. When the [GTP-heterodimer] is low, the addition of monomers does not occur and Catastrophe occurs! Centrosomes role in Cell division duplicate in parallel with DNA in S phase
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This note was uploaded on 05/28/2008 for the course BIOL D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.

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W3OutlineLec8 - Luis David Gomez 59866865 Bio 192 D103 Cell...

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