W4OutlineLec9

W4OutlineLec9 - Luis David Gomez 59866865 Bio 192 D103 Cell...

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 4 Lecture 9 Outline 1/ 28/08 Intermediate Filaments I. Elements of Cytoskeleton New Findings Bacterial tubulin FtsZ –minimal homology to MT, (major differences in A.A. sequence) Similarities/Differences F-actin Microtubules Depends on ATP hydrolysis Function: 1. Propel bacterial through cell 2. Cell migration Treadmilling depends on available concentrations of building blocks in the cytosol (ATP-g-actin) Motor proteins Myosins- have not covered yet Depends on GTP hydrolysis Function: 1. Cargo (proteins, organelles) transport (vesicles) --ER, Golgi, some Mitos 2. Cell Division 3. Segregation of chromosome 4. Mitotic Spindle—attach to kinetochorees Dynamic instability depends on available concentration of building blocks in the cytosol (free GTP alpha, beta tubulin) Motor Proteins Dynein Kinesin Back to the intermediate filaments (IF) a. Size : Larger than actin, smaller than MT—10 micrometers b. Biochemically hetergenous : at least 70 genes encode for IF in mammal’s cells
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W4OutlineLec9 - Luis David Gomez 59866865 Bio 192 D103 Cell...

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