W4OutlineLec10

W4OutlineLec10 - Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 4 Lecture 10 Outline 1 30/08 CQ What do you think of D103 Too much

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 4 Lecture 10 Outline 1/ 30/08 CQ What do you think of D103???? Too much Material! Protein Sorting What determines the identity of an organelle? By immunoflouresence yes But not by standard EM 1. Unique protein composition 2. Lipid composition—cardiolipin 3. Unique localization within the cell all three must be used to determine unique identity Analogous to an Airport according to Dr. Suetterlin Sorting signal—encoded by DNA, part of the protein, necessary (for sorting) and sufficient for transport of any neutral protein Translocation state—folded (nucleus) or unfolded Translocation machinery Energy Source—uses ATP or GTP, none? Release Refolding Sorting Signal Overview Nucleus-stays on ER—two options Mitos-partially removed Nuclear import/export NLS-nuclear localization signal is recognized by Importin form a complex Receptor takes cargo to translocalization machinery (nuclear pore) Ran-GTP leads to directionally, small GTPase
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This note was uploaded on 05/28/2008 for the course BIOL D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.

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W4OutlineLec10 - Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 4 Lecture 10 Outline 1 30/08 CQ What do you think of D103 Too much

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