This preview shows page 1. Sign up to view the full content.
Unformatted text preview: Ribosome lines up with translocon pore The ribosomes of the rER only translate proteins of the ER or secretary pathway Translocation —occurs co-translationally The translocon has many transmembrane domains, pore is not always open however we do not know how Proteins do not always need sorting signal to end up in ER however they do need a 20 AA hydrophobic domain Type 1- C terminus in Cytosol Type 2-C terminus in ER lumen Sequential Manipulations of a secratory pathway 1. Glycosilation- N-linked 2. Formation of S=S (disulfide) bridges 3. Oligomerization Protein Degradation by Proteosome--ubiquitin tags lable for breakdown serves as quality control...
View Full Document
This note was uploaded on 05/28/2008 for the course BIOL D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.
- Winter '08
- cell biology