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W6OutlineLec15 - amino acids—Lec 15 p 15...

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Luis David Gomez 59866865 Bio 192 D103 Cell Biology Week 6 Lecture 15 Outline 2/11/08 Signaling Overview Download 11 Principles of Signaling and Review Article. Cells all have the same principles of signaling. Not going to memorize pathways for example TGFB. But we will try to recognize the principles. Lec 15 p. 4 Review of Atomic Structure Understand the molecular basis for hydrophobic and hydrophyllic C.Q. Which statement is true regarding is the relative strength of these types of interactions? -Ionic bonds and Covalent bonds are stronger than Van der Waals forces or hydrogen bonds. Sharing of Electrons Covalent—sharing of electrons Noncovalent—unequal sharing of electrons A result of the relative difference of Electronegativity Ionic—no sharing of electrons Hydrogen Bonding—hydrogen bonds interact with dipoles of water molecules Amino Acids—understand sharing of electrons and apply it to
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Unformatted text preview: amino acids—Lec 15 p. 15 Proline—backbone is kinked in a certain way, cannot rotate about a praline, important in signaling, never found in alpha helical region Summation of amino acid interactions dictate overall protein interactions with other proteins--change one or two Amino acids CONFORMATIONAL CHANGE Calmodulin—binding of Ca2+ (ligands) interacts with acidic a.a. and completely changes the structure (to cause conformational changes) affinity—strength with which someone holds on specificity—selection of one ligand over another pointless to remember ALL subdomains Y(a.a.)### (location is peptide chain) gets phosphorylated p(hosphorylate hydroxyl group)A.A.#### --cannot phosphorylate one at a time, both residues much be phosphorylated at once by special kinase (adds Phosphate)...
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W6OutlineLec15 - amino acids—Lec 15 p 15...

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