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Unformatted text preview: 2 nd messengers can be anything from gas, nucleotides, peptides, ions—basically, almost any type of molecule. They activate downstream transcription by interacting with PKC/PKA, for example, and causing the catalytic subunit to dissociate from the regulatory subunit. 2 nd messengers diffuse in a concentration gradient from their source, and depending on inhibitory enzymes or sequestering proteins then they will diffuse throughout the cytosol are variable rates. 3. Please fill in the table. Pathway Does the receptor have intrinsic kinase activity Molecules that transduce the signal TGFB Yes 1 point SMAD 1 point Cytokine No 1 point STAT 1 point Receptor tyrosine kinase Yes 1 point MAP Kinases 1 point 4. 1,2-diacylglycerol (DAG) activates which of the following enzymes? a. Protein kinase C b. Protein kinase A c. Map kinase d. Tyrosine kinase PKA is part of Adenylyl cyclase pathway. MAP kinases are found on Tyrosine Kinase receptors....
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- Winter '08
- cell biology, tyrosine kinase