This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: The mitotic spindle during mitosis is composed of several different aspects: During which stage of the cell cycle is the chromosome content of a mammalian liver cell 1 n ? a. G 1 b. S c. G 2 d. none of the above During the cell cycle, DNA content in mammals is 2n, diploid. After S2 phase, once the DNA has been duplicated it is 4n, tetraploid. Only after meosis is DNA content is 1n, one copy of each chromosome. If the spindle assembly checkpoint malfunctioned and the cell begins anaphase before microtubules attached to kinetochores on both sister chromatids, what is the result? If proper spindle assembly does not occur, then NONDISJUCTION would be the most likely result. What is the role of p53 in mediating the cells cycle arrest in cells with DNA damage? p53 binds to the regulatory region of p21 gene, activating its transcription and synthesis of p21 protein that holds CDK/cyclin temporarily inactive...
View Full Document
This note was uploaded on 05/28/2008 for the course BIO SCI D103 taught by Professor Suetterlin/macgregor during the Winter '08 term at UC Irvine.
- Winter '08
- cell biology