34 - differential gene expression in the embryo

34 - differential gene expression in the embryo - Anterior...

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1 Anterior Posterior mRNA protein In a developing Drosophila embryo, the Gap Gene hunchback ( hb ) is expressed as RNA and protein by cells throughout the anterior half of the embryo. In contrast, most cells in the posterior half of the embryo do not transcribe this gene. Mutational analysis reveals that Hunchback protein is essential for normal development. Embryos that are homozygous for strong loss-of- -function alleles at the hb locus fail to form the anterior structures. The functional domain where hb activity is required for normal development closely matches thespatial pattern of Hunchback protein expression. hunchback functional domain Gap genes like hunchback are the first genes to be transcribed during the development of the fly embryo. But … the fertilized egg is composed of RNAs and proteins that were synthesized by the mother fly during egg formation, called oogenesis . Life-cycle of the fruitfly Drosophila melanogaster The fruitfly embryo hatches as a larva approximately 1 day after fertilization. The larva develops through
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34 - differential gene expression in the embryo - Anterior...

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