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bipn100 w06 m2key - BlPN 100 Mammalian Physiology 1 Name...

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Unformatted text preview: BlPN 100, Mammalian Physiology 1 Name: Winter, 2006 2nd. Midterm Exam ID. #2 March 3, 2006 Page I ~ % l. (12 points). Circle the correct answer or Fill in the blanks: A. Muscle spindles ark receptors that are activated by: § ZEfiZC éfi Wu — ® - amped B The patellar (knee jerk) reflex IS a flexor .eflex on th- 0 contralateral side C. In a relaxed muscle the spindle sensory neurons ar‘__. 2?} For the following, indiCate whether the rate of firing of muscle spindle sensory neurons increases, $4 decreases, or remains the same: 5W5 D During an isotonic contraction in a normal muscle: {36/4 Hg mg [35$ MI: E. During an isotonic contraction in a normal muscle when a load 15 added; TEA/$4933 __ F. During an isotonic contraction in a muscle if the axons of the gamma motoneurons are cut: DECREA 56$ . 2 {18 points) You are enjoying a nice day at the world famous San Diego Zoo and suddenly an angry gorilla gets loose and heads straight to you. List the appropriate change 1n your Worgans the {W corresponding types of receptor involved, and whether it is exoitatory or inhibitory by this strong In mu etIC stimulation. Effector Organ A Pupil of eye WWW W cm: 'S’W‘EAWNG’ L“ 3. (18 points). A pharmaceutical company developed several drugs thatinteract withthetransduction A system of a hormone whose receptor is coupled to Gs For the following, indicate whether the drug will increase (T) or decrease (l) the effects of the hormone, and which step is affected: Q 5 A. Drug bind to the hormone bin ng site of the receptor but d n tactivate it: weak 5, t} m M binding or creamrtit #OFaciwe Wflwfl B. Dru inhibits the GTPase activity ofG , W0 fgam‘ne G‘s me, ’7" 041, Worth/QM QWfler fer-10614 C. Dru inhibits adenylyICyclase ”(Wk f less ado/cam 9+ ?mxle/(m Ktvmse A fix D Dmf‘iéi‘iifie’ttéfiahfiz Im at WW We WW E Dru‘il inhibits cAMP €7me CAMP WW4,“ mm remain I’uglt f‘cr We,» fie/17084! F. Drug inhibits Protein phos WPMWQ‘L itcfhimiiw Lari“ MW Winter, 2006 2nd Midterm Exam ID. #: March 3, 2006 Page 2 BIPN 100, Mammalian Physiology 1 Name: Kg 2 4. (14 points) A young mother of a 2 month-old baby was brought to the ER in a coma after a car accident that caused a cerebral concussion MRI showed the main problem was edema (swelling) and a t small hemorrage at the base of the brain. Fortunately, she recovered and was released apparently Em healthy. But a few days later she returned complaining of unquenchahle thirst, frequent urination with large volumes, and noted that, although she had plenty of milk, her baby seemed to labor excessively while suckling her breast and nursing him took much longer than before the accident Urinalysis showed no glucose in the urine. Blood tests showed she was dehydrated with elevated plasma osmolarity ACTH, TSH, and Growth hormone levels were normal A Name two hormones and their actions, so that their absence could account for all of the above ,. e Ewwsmm Mu ’0 54% MIL :20 3-9 Wngptoms: OXYTOCIN alcoaflfffmfi 1;?me nele bjw Winn Zak" ADP; athsomegm » m 64365 tho me #171125 SDRPTIM / VIA/4317c; 1N RébeSE TD 05m» ‘U‘l‘i" or ‘6 Blood awe. Absence Wfiylauhqqkflm B Whatwasdamaged) theacciderntocausegfthe nonnalities? :‘fl; WWW AbeyeHomue Secrehnficall; WW www WW? fcwféimflmw new W”‘Yfl°’¥5éfi?i%mmzl [94: C 4» fl W5 (12 points) For the following conditions In striated muscle, indicate if the myosin heads are bound toactinor free, what HMS), ornone, are bound toordissociating from myosimandthe value ofthe N1} angle between the filaments and the crossbrid_ . a. or, if It is changing, from what to what Relaxed State Low ATP,Hi Ca DmgthE‘towsrsvoke: , A . . fig; 39ft? 5° 2%; 2 6. '(12 points). A Draw a plot of the membrane potential vs. time of a cell of the Sine-Atrial node during resting conditions. Indicate which ion channels are involved in the pacemaker potential, and in the rising portion, and the falling portion of the action potential B. What channels open during stimulation of the vagus nerve and how do they affect the frequency of action potentials (increase, decrease, no change)? 3 Va no s‘VLIMw’ZAW8 K+Citdmw¢flo oul’h/ #4541137» 0i 6% refinamhw oaeiwh’aflo “Wu Xmal 1(ij MWalfwéi/maaj BIPN 100, Mammalian Physiology I Name: Winter, 2006 2nd. Midterm Exam ID. #: March 3, 2006 Page 3 7. (12 points) Draw the electrocardiogram you expect (lead 11) in a patient that suffered a lesion that killed all the cells of the S—A node. Indicate the correct letters corresponding to each wave and note any abnormal or missing waves, as well as whether the waves will be rhythmic or not, and any changes fl U in their frequency in the ECG of this patient. 9 “‘l ’1’ 5 +5 I) .. RML (Whode {/0 Wm) [92an é P36 (zr‘lseov) bwi WW3 SIM m (Nev/mm) 8. (14 points). Below is PV diagram of the left ventricle during one cardiac cycle. Fill in the blanks for the following events with either the single location (A, B, C, D) or the appropriate segment (B-A-D, B-C, A-B-C-D, etc.) in the correct sequence. W“ B Pressure D A C 2 ft an. Volume CU The correct sequence of a full cycle, starting with ventricular filling _A_ The first heart sound L The second heart sound 13 The after-load A The pre—load B‘C’A The period when a murmur due to either stenosis of the mitral valve or incompetence of the aortic valve can be heard. A ’D’B The period when a murmur due to either stenosis of the aortic valve or incompetence of the mitral valve can be heard. BIPN 100, Mammalian Physiology I Name: KEY Winter, 2006 2nd. Midterm Exam ID. #: March 3, 2006 Page 4 9. (12 points). List or diagram the transport systems that cause relaxation of myocardial cells; include the directions of transport, where are they located in the myocardial cells, and what are their energy requirements (i.e., primary or secondary active transport, energy source)? Be sure to specify stoichiome when a ro riate. try PP P 3N ? (l @14- GOOD THINKING AND GOOD LUCK”!!! ...
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