chem206 Rapor-7 - ABSTRACT In this experiment the aim was...

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ABSTRACT: In this experiment the aim was to purify aspirin, acetaminophen and caffeine from the  analgesic and aspirin tablet by combining different techniques of separation that have been  learnt   so   for   in   organic   chemistry   I   laboratory   such   as   crystallization   ,   using   solubility  properties, acid- bas extraction, melting point determination with SMP10 and functional group  determination using IR spectroscopy. This experiment consists of two parts: separation of the components in (a)aqueous  layer and (b)organic layer of an analgesic-aspirin solution.In the first part, which was the  separation of aqueous layer, after filtration of the layer of interest, solution was acidified with  3 M HCl. And waited for evaporation to obtain the aspirin amount. In the second part, caffeine was obtained with the evaporation of CH2Cl2 and water  removal   using   CaCl2.   Binder   and   acetaminophen   was   separated   with   the   help   of   the  solubility of acetaminophen in IPA. Finally, 0.031 grams of aspirin, 0.174 grams of caffeine,  0.159 grams of binder and 0.337 grams of acetaminophen were obtained with the analysis of  0.614 grams of Tylol Analgesic and 0.592 grams of aspirin mixture solution. The melting points of acetaminophen and caffeine were found to be between 163-167   C and 220-224   C respectively. INTRODUCTION: The aim of this experiment was to apply all the separation and purity determination  techniques with the help of physical properties.  Chemically active separation enables chemically different substances to be analyzed  and separated upon their physical properties such as solubility, acidity and basisity.  By the  combination of polar and non polar solvent with acids or bases, various components of a  substance may be separated.   A polar substance will dissolve the polar component of the  mixture   so   that   only   using   solubility,   polar   and   non-polar   substances   are   available   for  separation.  Remaining substances are -further- able to be separated with chemically active  extraction using acid-base reactions.   Analgesics are mainly synthetic painkillers where endorphin is the natural one. Analgesics  generally act on peripheral and central nervous system. The main effective substance of a  regular analgesic is paracetamol (also known as acetaminophen)( C 8 H 9 N    O     2   ). Those drugs may  be so strong to use for narcotic purposes such as morphine.    1
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The   most   common  analgesic  type  known  is   aspirin,  which  is   also   known  as  acetylsalicylic acid( C 7 H 6 O 3 ) . Aspirin is from non-steroidal anti-inflammatory drugs  class. Main  role of an aspirin  (ASA)  is to reduce  pain or ache  in other  words  serve  as a painkiller. But, 
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