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Unformatted text preview: ABSTRACT: In this experiment the aim was to purify aspirin, acetaminophen and caffeine from the analgesic and aspirin tablet by combining different techniques of separation that have been learnt so for in organic chemistry I laboratory such as crystallization , using solubility properties, acid- bas extraction, melting point determination with SMP10 and functional group determination using IR spectroscopy. This experiment consists of two parts: separation of the components in (a)aqueous layer and (b)organic layer of an analgesic-aspirin solution.In the first part, which was the separation of aqueous layer, after filtration of the layer of interest, solution was acidified with 3 M HCl. And waited for evaporation to obtain the aspirin amount. In the second part, caffeine was obtained with the evaporation of CH2Cl2 and water removal using CaCl2. Binder and acetaminophen was separated with the help of the solubility of acetaminophen in IPA. Finally, 0.031 grams of aspirin, 0.174 grams of caffeine, 0.159 grams of binder and 0.337 grams of acetaminophen were obtained with the analysis of 0.614 grams of Tylol Analgesic and 0.592 grams of aspirin mixture solution. The melting points of acetaminophen and caffeine were found to be between 163-167  C and 220-224  C respectively. INTRODUCTION: The aim of this experiment was to apply all the separation and purity determination techniques with the help of physical properties. Chemically active separation enables chemically different substances to be analyzed and separated upon their physical properties such as solubility, acidity and basisity. By the combination of polar and non polar solvent with acids or bases, various components of a substance may be separated. A polar substance will dissolve the polar component of the mixture so that only using solubility, polar and non-polar substances are available for separation. Remaining substances are -further- able to be separated with chemically active extraction using acid-base reactions. Analgesics are mainly synthetic painkillers where endorphin is the natural one. Analgesics generally act on peripheral and central nervous system. The main effective substance of a regular analgesic is paracetamol (also known as acetaminophen)(C 8 H 9 N O 2 ). Those drugs may be so strong to use for narcotic purposes such as morphine. 1 The most common analgesic type known is aspirin, which is also known as acetylsalicylic acid(C 7 H 6 O 3 ). Aspirin is from non-steroidal anti-inflammatory drugs class. Main )....
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