Study Guide for Dr. Vierling’s material:
Each set of lecture notes typically has a set of learning goals or list of things you
should know. Pay attention to these. Often the chapter reading covered material that is
not in the notes. You are not directly responsible for material not covered in the notes. In
lecture I tried (don’t know if I succeeded) to focus more on basic principles and recurring
themes, and did not go through every specific example in detail (for example every type
of carbohydrate binding protein, every type of membrane channel, every type of DNA
binding protein). Focus on material covered in class and in discussion and clicker
questions. Material in the notes not specifically covered in class should be easy for you to
understand (not memorize) in light of what you have learned.
All of the figures used in the slides in the lecture notes were chosen carefully to
represent a specific point. Therefore, you should try to understand the major points on
each slide. If a figure looks totally foreign to you, look it up in the text to understand it.
Throughout studying, try to find the connecting threads of biochemistry. That is, focus
on understanding the common, basic energetic (thermodynamic and kinetic) principles
and on the recurring chemical reactions and properties of functional groups. Hopefully
you will recognize how information presented during the semester builds on itself. There
are always some things to memorize, but if you consider them in a basic framework of
thermodynamics, kinetic and chemical principles, many things fit together and are logical
consequences of each other, meaning less memorization.
Make sure you can do the homework problems without any trouble. This
means you should be able to apply all the different equations we have covered to
different types of problems and questions. This requires an understanding of how
the equations relate to biochemical processes, not just how to plug in numbers!
I have taken advantage of many websites and jmols during lecture. While it is not
essential that you memorize any of these materials specifically, use them if they help you
learn the basic principles or visualize a process better. They may offer a nice break from
other parts of studying as well.
LIPIDS AND MEMBRANES
structures for fatty acids, glycerol, triacylglycerols, and
glycerophospholipids. Note the different charge properties of glycerophospholipids.
Recognize the general structure of sphingolipids.
Be able to describe the type of
linkages attaching the various substituents to the glycerol or sphingosine backbone
(ester, phosphate ester, amide, glycosidic bond, etc.)
the general structure
of the sterol nucleus and the structure of cholesterol.
2. Explain fatty acid short-hand nomenclature, e.g., how many carbons and double