Lecture 5 - BIO 317 Principles of Cellular Signaling...

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1 BIO 317 Principles of Cellular Signaling Lecture 5 “The axon doesn’t think. It only ax.” - George Bishop, 1965 • Axons are highly specialized for conduction • APs are brief and can follow at high frequencies • Only AP timing is important (time and frequency) not AP amplitude or duration • 2 major voltage-gated channel types – Na + , K +
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2 Other plasma membranes have many more varieties of channels • K + Channels - greatest diversity • Na + Channels - less diverse • Ca ++ Channels - ubiquitous – Not in axons – Essential for many biological responses Molecular Structures of Voltage- gated Channels are Similar • Family of proteins encoded by related genes • probably arose from a single ancestral gene. • Na v and Ca v channels - 1 large protein • K v channels - aggregate of 4 smaller proteins, each structurally similar to a single one of the Na v domains
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3 • Family of proteins encoded by related genes • probably arose from a single ancestral gene. • Na
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Lecture 5 - BIO 317 Principles of Cellular Signaling...

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