Lecture 4 - 1 BIO 317 Principles of Cellular Signaling Lecture 4 Effect of E m on Ion Flux E Na = 58 mV E K =-81 mV time Focus on Na and K Na flux

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Unformatted text preview: 1 BIO 317 Principles of Cellular Signaling Lecture 4 Effect of E m on Ion Flux E Na = 58 mV E K = -81 mV time Focus on Na + and K + Na + flux K + flux 2 Animation What Determines the Threshold Voltage for the Action Potential? g K E m " E K ( ) " g Na E m " E Na ( ) = i K i Na When E m is at resting potential, K + and Na + currents are in balance. Assume that g K and g Na are not voltage dependent. What happens when E m is depolarized 15 mV from -70 mV to -55 mV? g K E m " E K ( ) " g Na E m " E Na ( ) > i K i Na i K would increase in amplitude because the driving force would increase. i Na would decrease in amplitude because the driving force would decrease. Since i K > - i Na , K + current is the dominant inFuence and E m will repolarize to the resting potential, -70 mV. 3 What Determines the Threshold Voltage for the Action Potential? Assume that g K and g Na ARE voltage dependent. What happens when E m is depolarized 15 mV from -70 mV to -55 mV?...
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This note was uploaded on 05/18/2008 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

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Lecture 4 - 1 BIO 317 Principles of Cellular Signaling Lecture 4 Effect of E m on Ion Flux E Na = 58 mV E K =-81 mV time Focus on Na and K Na flux

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