Lecture 1 - 1 Principles of Cell Communication Dr. Joerg R....

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Unformatted text preview: 1 Principles of Cell Communication Dr. Joerg R. Leheste New York College of Osteopathic Medicine jleheste@nyit.edu Reading Assignments Alberts (4th ed.), Chapter 15 p831-845 Basic Components of a Signaling Pathway Kinases Phosphatases GTP-binding Proteins Proteins, peptides, aas Nucleotides Steroids, retinoids Fatty acids NO, CO 2 Cell Surface & Intracellular Receptors Kd: Dissociation constant 1 0-8 M [Ligand] binding sites occupied Short-Range Signaling Development Immune response Immediate environment 3 Long-Range Signaling Synaptic signaling Fast 100m/s High local concentration Direct connection Endocrine signaling Slow Low local concentration Specific receptors Mechanisms of Specificity 4 Velocity of Response Autocrine Signaling and Cancer Community effect 5 Gap Junctions in Signaling Signal Complexity Combinational control 6 Receptor vs. Internal Differences Rapid Turnover Sharpens Response Example 7...
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Lecture 1 - 1 Principles of Cell Communication Dr. Joerg R....

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