Lecture 1 - 1 Principles of Cell Communication Dr Joerg R...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Principles of Cell Communication Dr. Joerg R. Leheste New York College of Osteopathic Medicine [email protected] Reading Assignments – Alberts (4th ed.), Chapter 15 p831-845 Basic Components of a Signaling Pathway • Kinases • Phosphatases • GTP-binding Proteins • … • Proteins, peptides, aa’s • Nucleotides • Steroids, retinoids • Fatty acids • NO, CO 2 Cell Surface & Intracellular Receptors Kd: Dissociation constant ≤ 1 0-8 M [Ligand] – ½ binding sites occupied Short-Range Signaling • Development • Immune response • Immediate environment 3 Long-Range Signaling Synaptic signaling Æ Fast 100m/s Æ High local concentration Æ Direct connection Endocrine signaling Æ Slow Æ Low local concentration Æ Specific receptors Mechanisms of Specificity 4 Velocity of Response Autocrine Signaling and Cancer Community effect 5 Gap Junctions in Signaling Signal Complexity Combinational control 6 Receptor vs. Internal Differences Rapid Turnover Sharpens Response Example 7...
View Full Document

This note was uploaded on 05/18/2008 for the course BIO 317 taught by Professor Simonhalegoua during the Fall '08 term at SUNY Stony Brook.

Page1 / 16

Lecture 1 - 1 Principles of Cell Communication Dr Joerg R...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online