Practice_exam_2 - Name CHM 3218 Spring 2008 Practice Examination#2 University of Florida Honor Code Statement"On my honor I have neither given nor

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__________________________________ Name 1 CHM 3218 Spring 2008 Practice Examination #2 University of Florida Honor Code Statement: "On my honor, I have neither given nor received unauthorized aid in doing this assignment." __________________________________ Student signature Instructions : You would have two hours to complete this exam. All books, notes and other aids would be prohibited, but molecular models and calculators would be allowed. Be sure to budget your time and answer questions briefly but completely. To receive partial credit for incorrect answers, show your work, particularly in problems involving calculations. Write your name on each page. 1. The enzyme hexokinase catalyzes the first step in glucose metabolism in eukaryotes, following its transport into cells. ( Total 36 points ). Glucose + ATP Hexokinase Glucose-6-phosphate+A D P a. The following data were collected from studies of human erythrocytes ( The Red Blood Cell , Vol. 2, p. 709, Academic Press (1975)). Note that D-mannitol is a six-carbon sugar alcohol whose exact structure is not significant for your answer. The permeability coefficient reflects how fast a molecule moves across a membrane (bigger number = faster movement). Permeability coefficient (cm / s) Membrane sample D-glucose D-mannitol Synthetic bilayer containing lipids only 2.4 × 10 -10 4.4 × 10 -11 Intact human erythrocyte 2.0 × 10 -4 5.0 × 10 -9 Glucose transport by erythrocytes does not require ATP hydrolysis or the presence of any other small molecules or ions. Based on all the information provided, predict the type of membrane transport used for glucose by these cells and briefly explain how your answer is consistent with all the experimental observations. (6 points) .
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__________________________________ Name 2 b. Would you predict that the equilibrium position of the hexokinase-catalyzed reaction would strongly favor reactants, strongly favor products or lie near the middle? Briefly explain your answer. (4 points) .
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This note was uploaded on 05/21/2008 for the course BCH 3218 taught by Professor Johnsteward during the Spring '08 term at University of Florida.

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Practice_exam_2 - Name CHM 3218 Spring 2008 Practice Examination#2 University of Florida Honor Code Statement"On my honor I have neither given nor

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