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Unformatted text preview: EN580.223 BIOLOGICAL MODELS AND SIMULATIONS March 3, 2008 The Johns Hopkins University QUIZ #2 Answer Key 1. Blood flow in the circulatory system is approximately 5 l/min. Consider concentration of oxygen in the aorta of 3x10-3 mlO 2 /ml blood (corresponding to partial pressure of 100 mmHg) and in the vena cava of 1.2x10-3 mlO 2 /ml blood (corresponding to partial pressure of 40 mmHg). Formulate mass balance relation to calculate the amount of oxygen transferred to tissue per minute, E 02 . [20 points] C in Q in-C out Q out =E O2 , 3 3 3 2 2 2 (3 10 1.2 10 ) 5 10 1.8 5 9 min min mlO mlO mlO ml blood--- = = 2. AVASTIN is an anti-cancer drug made by Genentech. It is an antibody (large molecule) to vascular endothelial growth factor, VEGF. It is administered as an intravenous infusion (dose 5 mg/kg, infusion duration is 60 min) every 14 days until disease progression. Dose is the total amount of the drug injected at a constant rate during 60 min. During 14 days following injection the drug is slowly eliminated (cleared) from the blood. Assume that following injection the drug is slowly eliminated (cleared) from the blood....
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- Fall '08