Mitosis and Meiosis 92607

Mitosis and Meiosis 92607 - Mitosis and Meiosis 1. Cell...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Mitosis and Meiosis 1. Cell cycle for most cells has two phases: Division and Interphase Interphase has three sub-phases: G 1 ---S---G 2 Division: Mitosis or Meiosis and Cytokinesis Purpose of G 1 prepare for S (may at some point go to G 0 ) Therefore, G 1 can be thought of as a transition phase Problem: How are decisions made? Must activate proteins called Cyclin-dependent Kinases or Cdk’s Cdk’s catalyze the phosphorylation of specific (target) proteins. How is Cdk activated? Another protein binds to it, Cyclin forming what is termed a Cyclin- Cdk complex that then acts as a protein kinase and triggers the transition from G 1 to S. (INSIDE THE CELL****) However, major point!!!!!!!!!!!!!!!! One more substance is necessary to complete the transition!!!!!!!!!!!!!!!! Retinoblastoma protein, otherwise known as (RB). RB is an inhibitor that then must be inhibited!!!!!! Yes Cdk’s phosphorylate RB which then becomes inactive and only then can G 1 move to S Why so significant? Well, over stimulation (production of Cdk) leads to more inhibition of
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 05/27/2008 for the course BIOLOGY 107 taught by Professor Dr.abbott during the Fall '08 term at UConn.

Page1 / 2

Mitosis and Meiosis 92607 - Mitosis and Meiosis 1. Cell...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online