Practical U - Melinda Salomon 27 June 2007 Practical U...

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Melinda Salomon 27 June 2007 Practical U – Friedel-Crafts Reaction: Fluorescein The purpose of this experiment is to perform a Friedel-Crafts reaction of phthalic anhydride with resorcinol in the presence of zinc chloride to yield fluorescein. Mechanism - MW Amount mmol bp (C) mp (C) d Anhydrous ZnCl2 100.84 240mg 2.38 756 275 2.907 Phthalic anhydride 148.12 300mg 2.03 295 131 1.53 Resorcinol 110.11 446mg 4.05 280 110 1.28 Concentrated HCl (x2) 0.2mL 0.1M Aqueous NaOH 10mL 2M HCl 36.46 Drop-wise addition H2O 18.02 (x2) 2mL 0.222 100 0 Fluorescein (product) 332.306 2.025 314-316 *Above table information was found via search on www.wikipedia.com The procedure for this experiment can be found in the Organic Chemistry Laboratory, Practical Examination, General Guidelines handout – Practical U.
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Procedure - 1. Heat 240mg anhydrous zinc chloride in a 10-cm test tube until no more moisture evolves. 2.
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Practical U - Melinda Salomon 27 June 2007 Practical U...

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