Ketones, Triacylglycerols and Phospholipds

Ketones, Triacylglycerols and Phospholipds - + OH OPO 3...

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Ketogenesis H 3 C SCoA O H 3 C SCoA O + CoASH Thiolase Acetyl-CoA Acetyl Transferase H 3 C SCoA O O Acetoacetyl-CoA Acetyl-CoA + H 2 O CoASH - O SCoA O O OH CH 3 HMG-CoA HMG-CoA Synthase Acetyl-CoA H 3 C O - O O Acetoacetate HMG-CoA Lyase CO 2 Non-Enzymatic H 3 C CH 3 O Acetone NADH + H + NAD + Beta-Hydroxy butyrate dHase H 3 C O - OH O Beta-Hydroxy Butyrate Ketone Body Catabolism H 3 C O - OH O Beta-Hydroxy Butyrate H 3 C O - O O Acetoacetate Beta-Hydroxy butyrate dHase NAD + NADH + H + - O CoA O O - O O - O O Succinyl-CoA Succinate H 3 C CoA O O Acetoacetyl CoA CoA H 3 C CoA O H 3 C CoA O + 3-Acetoacyl-CoA Transferase * Thiolase *Key Enzyme -missing from Liver Synthesis of Triacylglycerols and Phospholipids OH OPO 3 2- O R CoA O CoA DHAP Acyltransferase DHAP O OPO 3 2- O R O Acyl-DHAP Glycerol-3-P dHase NADP + NADPH + H
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Unformatted text preview: + OH OPO 3 2-OH R CoA O CoA Glycerol-3-P Acyltransferase NADPH + H + NADP + Acyl-DHAP Reductase O OPO 3 2-OH R O Glycerol-3-P Lysophosphatidic Acid R CoA O CoA 1-acylglycerol-3-P Acyltransferase O OPO 3 2-R O O R O Phospholipids "Alcohol" Phosphatidic Acid O HO R O O R O P i Phosphatidic Acid phosphatase R CoA O CoA HO HO O R O 2-monoacylglycerol Diacylglycerol Acyltransferase Diacylglycerol R CoA O CoA O O R O O R' O R" O Diacylglycerol Acyltransferase Triacylglycerol (From Intestinal Digestion)...
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This note was uploaded on 05/31/2008 for the course CHEM 153C taught by Professor Weiss during the Spring '08 term at UCLA.

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