UCLA Midterm Bio

UCLA Midterm Bio - Your Name_ Midterm 1 LS3 Section 2, Fall...

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Your Name__________________________________ Midterm 1 LS3 Section 2, Fall 2005 October 25, 2005 Question 1 (40 points): 1. (8 points) In a test tube containing a mixture of amino acids in a simple buffer solution, the amino acids do not generally form peptide bonds, but instead remain as free amino acids. Why is this? Briefly explain your answer with respect to both free energy and activation energy. 2. (8 points) The initiation and elongation of protein synthesis in a eukaryotic cell is a complicated process requiring a considerable input of energy. If the first two amino acids of a polypeptide chain are Methionine (Met) and Glutamine (Gln), how many ATP and GTP molecules must be hydrolyzed by the time a peptide bond is formed between these two amino acids? (The textbook figures of translation initiation and elongation are at the end of the exam, but please be aware that additional information may be needed to answer this question.) Met + Gln Met-Gln (linked to Gln tRNA) 1
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Your Name__________________________________ 3. (8 points) List the names of all enzymes needed to carry out the above reaction in a living eukaryotic cell. (Think carefully about the definition of an enzyme and about your knowledge of the above reactions.) 4. (8 points) One of the key steps in the recruitment of an aminoacyl tRNA to the ribosome is the interaction between the anticodon of the tRNA and the codon of the mRNA. What type of bond is of central importance for this interaction? 5. (8 points) The genetic code table and the Wobble table are shown at the end of the exam. The genetic code table shows the possible codons for Gln. However, the anticodon sequences are not shown. With respect to the concept that a cell attempts to function as efficiently as possible, what is the minimal number of tRNA species that must exist for Gln? Please write down the anticodon sequence(s) for this or these tRNAs. Label the 5’ and 3’ ends of the anticodon(s). 2
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Your Name__________________________________ Question II (60 points): The drug imatinib, commonly known as Gleevec, represents a remarkable success in using the results of molecular biology research for the development of a potent cancer therapeutic. Gleevec leads to remarkably efficient remission of a leukemia (i.e. blood- cell cancer) known as CML. CML is caused by a genetic change in which two
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This note was uploaded on 05/28/2008 for the course BIO 112 taught by Professor Estella during the Spring '08 term at UCLA.

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UCLA Midterm Bio - Your Name_ Midterm 1 LS3 Section 2, Fall...

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