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Question bank 2008 - HOLLINGSWORTH QUESTION BANK 2008 All...

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1 HOLLINGSWORTH QUESTION BANK 2008 All questions are from midterms or finals generated by me from 1996 to 2006. Please note that many questions integrate ideas from more than one lecture and therefore may be applicable to more than one category. However, to keep the size of the bank manageable, each question is only listed once. (Answer key at the back). Table of contents: A. Vocabulary 1 B. Mendelian Genetics 2 C. Exceptions to Mendelian Genetics 6 D. Mitosis and Meiosis 13 E. Sex linkage and sex-limited traits 17 F. Pedigree Analysis 20 G. χ 2 Problems 23 H . Linkage and Gene Mapping: Inter-genic recombination 26 I. Chromosome Aberrations 37 J. DNA Structure 42 K. DNA replication, mismatch repair and recombination 45 L. Mutation 50 M. Linkage and Gene Mapping: Intra-genic recombination 55 N. Gene Function 61 O. Prokaryotic Genetics 67 P. Extrachromosomal Inheritance 71 Answer Key 72 A. VOCABULARY A1. (10 points). For each of the terms in the left column, choose the best matching phrase in the right column and put the number in the space next to the letter. _____ A . alleles 1. less than 100% of the individuals possessing a particular genotype display it in their phenotype _____ B. independent assortment 2. one gene affecting more than one phenotype _____ C. heterozygote 3 . the alleles of one gene mask the effects of alleles of another gene _____ D. locus 4. an individual with two different alleles of a gene _____ E. epistasis 5. observable characteristic _____ F. pleiotropy 6. alternate forms of a gene _____ G. reduced penetrance 7. alleles of one gene separate into gametes randomly with respect to alleles of other genes _____ H. tetratype 8. the relative chromosomal location of a gene _____ I. interference 9. one crossover along a chromosome makes a second nearby crossover less likely _____ J. phenotype 10. an ascus containing spores of four different genotypes A2. (5 points). Fill in the blank. a. During DNA synthesis, the _______________________strand is synthesized discontinuously. b. An allele that affects more than phenotype is __________________________. c. __________________________ is when the genotype of one locus masks the phenotype of a second locus.
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2 d. A base pair substitution that changes a purine on one strand to a pyrimidine is called a _______________________________. e. ________________________ describes the proportion of individuals of a given genotype that displays the phenotype associated with that genotype. B. MENDELIAN GENETICS: B1. A dominant allele is one that: A. expresses a phenotype only when homozygous. B. masks the expression of neighboring gene loci. C. expresses a phenotype only when heterozygous. D. suppresses the expression of genes at all loci. E. masks the expression of a recessive allele. B2 . In corn, gene A is necessary for seed color and is dominant to colorless ( a ). A pure-breeding colored plant is crossed to a pure-breeding colorless plant and the F1 progeny are all colored. When the F1 progeny are crossed, the F2 plants show a ratio of 3/4 colored: 1/4 colorless plants. If a colored plant from the F2 generation is picked at random and crossed with itself, what is the probability that more than one phenotype will be observed among a large number of its progeny?
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