Question Bank A

Question Bank A - BIO320-Spring 2008 Question bank A I. THE...

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BIO320-Spring 2008 Question bank A © 2008 mkernan 1 I. THE "CENTRAL DOGMA": DNA TO PROTEIN 1. The relationship between DNA, RNA and protein in living cells is often summarized like this: DNA RNA protein The arrows indicate that: A) Energy flows from DNA to protein, via an RNA intermediate. B) Information is transferred from DNA into protein, via an RNA intermediate. C) DNA is chemically converted into RNA, and RNA is converted into protein. D) Cells evolved from using only DNA to store information, to later forms that used RNA and protein. 2. Which of the following statements about proteins is FALSE? A. Proteins are translated as linear chains of amino acids. B. The amino acid sequence information in proteins can be transferred back into DNA by reverse transcriptase. C. Genes and the proteins they encode are colinear. D. After translation, some proteins are further processed into their functional form. E. During translation, amino acids are added only at the carboxy terminus of the polypeptide chain. 3. Of the following types of biological information, can any NOT be written or encoded in a DNA sequence? A) The primary amino-acid sequence of a cytosolic protein. B) The nucleotide sequence of a ribosomal RNA. . C) The instructions that tell RNA polymerase where to start transcribing a gene. D) An N-terminal sequence in a protein that will signal its export from the cell by secretion. E) All of these forms of information can be written or encoded in DNA. 4. In 1960, Brenner, Jacob and Meselson investigated protein synthesis in bacterial cells immediately after bacteriophage infection. They used density-labeling to distinguish old (pre-infection) ribosomes from newly- made ribosomes, and radioactive labelling to trace new RNA synthesis, to show that: A) New phage proteins were made on new ribosomes using old messenger RNA. B) New phage proteins were made on old ribosomes using new messenger RNA. C) New phage proteins were made on new ribosomes using new messenger RNA. D) New phage proteins were made on old ribosomes using old messenger RNA. 5. In 1964, Brenner, Jacob & Meselson showed that after bacteria were infected by phage, no new ribosomes were made but newly-made RNA was associated with old, bacterial ribosomes. They concluded that A) Translation precedes transcription in bacteria. B) The information needed to make a protein is carried by an RNA message, not by the ribosome. C) Phage proteins, but not bacterial proteins are made on ribosomes. D) A different ribosome is needed to make each type of protein. E) Bacterial ribosomes are denser than phage ribosomes. 6. By density gradient centrifugation and radiolabeling, Brenner, Jacob and Meselson showed that when bacteria are infected by phage and start to make phage proteins, they first must synthesize… A. new ribosomal proteins. B. new amino acids.
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Question Bank A - BIO320-Spring 2008 Question bank A I. THE...

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